The present study was carried out to investigate the effect of aspirin on the female reproductive organs in albino rats. (21) mature female albino rats (150-170gm) were divided into three groups: 1st group which treated as negative control group, it was drenched only 0.2 ml of PBS.2nd group was drenched with Aspirin(10 mg/Kg of B.W once daily for 14 days).3rd group was drenched with Aspirin (20 mg/Kg B.W once daily for 14 days). Our results showed that 2nd group and 3rd group demonstrated significantly decrease (P ≤ 0.05) in the values of plasma LH compared with control group. In values of plasma FSH hormone, the 2nd and 3rd groups showed significantly decreased (P ≤ 0.05) in the relation with the control group. On the other hand, the microscopic examination of the histopathological sections of uteri of all the treated and control groups showed that the 2nd group demonstrated mild hyperplasia and degeneration in the epithelial cells which lining the uterus and there is few numbers of uteri glands. Also marked hyperplasia and vacuolation of the epithelial cells which lines the uterus. In 3rd group, the histopathological examination of uteri elucidates profuse proliferation and irregular hyperplasia of smooth muscles in the wall of uterus, there is high infiltration of inflammatory cells and there is congestion of blood vessels. Also there is marked vacuolation of uterine epithelial cells and fewer and smaller uterine glands than the 2nd group and 1st (control) group. In ovaries of 2nd group showed markedly few follicular growth wave characterized by primary, secondary follicles and there is congestion and thrombi in the ovarian stroma. Also presence of large corpus luteum. But the histopathological changes in the ovaries of 3rd group animals showed more severity than 2nd group animals in which there are primary and secondary follicles with severe congestion and hemorrhage, also there is high numbers of corpus luteum. 1st (control) group was showed normal histological feature of uteri and ovaries. We conclude from the present study that different doses of aspirin can cause histopathological effects and hormonal disturbances in FSH and LH hormones.