The current study was conducted at the college of veterinary medicine, university of
basrah in the periods extended from 22/10/2016 to 22/1/2017. The present study is
designed to report the toxic effects of digoxin on kidney histologically and biochemically
by measuring kidney parameters urea and creatinine level in the serum. Maximum toxic
dose determined by using 2 rats dosed orally until clinical signs of toxicity became
prominent at 30mg for each rat and considered as MTD. The chronic toxicity study was
carried out on 48 adult rats divided into 4 groups. Control (G1) receive distilled water,
Low dose (G2) dosed with 1/20 MTD(1.5mg/kg) digoxin, Intermediate dose (G3) dosed
with 1/10 MTD(3mg/kg) digoxin and High dose (G4) dosed with 1/5 MTD(6mg/kg)
digoxin by oral gavage for 90 days. At the end of experiments all animals were sacrificed
and blood sample were collected for estimation of biochemical parameters of rat. Result
reveals histopathological changes presented as dilation/vaccuolation of renal tubules and
atrophy of glomeruli. There is a significant (P≤0.05) increase in serum urea and
creatinine level in high dose (G4) group when compared with other study group. We
conclude that high dose digoxin has toxic effect on renal tissue and lead to their damage.