Abstract
The present study is conduct to evaluated the deleterious effects of
administration of dimethylnitrosamine (DMN) on the some oxidative stress and lipid
profile parameters of laboratory male rats (Rattus rattus), we used eighteen adult male
rats randomly divided into three equal groups ( six in each). Group 1 (control) the
animals treated by given oral normal saline (0.2 ml), group 2 was treated by oral
dimethylnitrosamine 30 mg/kg/day, group 3 the animals were treated by oral Nacetylcysteine 300 mg/kg/day followed by dimethylnitrosamine 30 mg/kg/day. At the
end of experimental period, rats were sacrificed. Blood was collected by cardiac
puncture to investigate lipid profile and oxidative parameters including serum MDA,
glutathione, catalase, and SOD. Results showed a significant reduction in SOD,
Catalase, glutathione, and HDL, and a significant increase in MDA, LDL, total
cholesterol, triglyceride, after DMN treatment, while these changes were returned to
nearly normal level when they combined NAC with DMN treatment for the 30 days
treatment when compared with the control group.
Keywords