Abstract
Chediack-Higashi syndrome (CHS) is inherited autosomal recessive disorder
affected cattle and other species of animals and caused by LYST gene mutation, and
characterized by oculocutaneous albinism, variations of total and differential
leukocyte count , different severe infections, dysfunction of platelets and a bleeding
tendency.The study included 65 Iraqi water buffaloes of different ages and of both
sexes which was divided as 25 black buffaloes served as controls, 25 buffaloes with
patches or spotted animals and 15 white water buffaloes. The most important clinical
signed showed by the animals are, white, irregular coat, unpigmented skin, hairs,
eyes, with loss of appetite, emaciation, weakness, long hair than normal with tufts,
anemia, photophobia with oculocutaneous depigmentation, and dullness. Animals of
both sexes are affected specially those under one year of age. The results indicated a
significant increases (p<0.05) of body temperatures, pulse and respiratory rate of
diseased buffalo than in controls, However a significant decrease (P<0.05) has been
registered in erythrocytes (RBC), hemoglobin concentration (Hb), packed cell volume
(PCV) and main corpuscular hemoglobin concentration (MCHC), with no statistical
differences was detected in mean corpuscular hemoglobin (MCH), whereas the mean
corpuscular volume (MCV) was significantly increase (P<0.05). The results were
also show lymphocytosis, eosinophelia and basophelia with Nutropenia and
thrombocytopenia with prolonged bleeding time.Conclusion: It has been to our
knowledge that the current study is the first one in this area and the syndrome affected
the Iraqi buffaloes and caused a clear clinical and hematological signs.
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