Authors
Abstract
Recurrent abortion is a worldwide problem, with undefined causes. Apoptosis could
play a major role in the process. The Objective of the work to detect the expression
of p53 protein at the materno-fetal interface in patients with recurrent pregnancy loss
(RPL). Immunohistochemistry analysis of P53 protein using paraffin embedded
sections of curate samples obtained from 40 women divided into three groups : 16
women with recurrent abortion as postive with toxoplasmosis,10 women with
recurrent abortion negative of toxoplasmosis and14 women with no histry of abortion
as control group .
The mean value of the expression of P53 protein was (40.87± 7.54),which is
significantly higher than that of the second group(28.2± 4.89),and the third group
(13.07± 4.49). The high expression of p53 protein in women with RPL may have a
role in accelerating placental apoptosis leading to failure of pregnancy.
Keywords
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