The present study assessed the effects of O-anisidine hydrochloride and the
ameliorating effect of Quercetin dihydrate in laboratory rats. Sixteen male and thirty
two female rats (Rattus norvegicus) were used and divided into eight equal groups of
two male and four female rats each. The results revealed that the treatment with Oanisidine
hydrochloride for 30 days (T1, T2 and T3 groups) caused significant
decrease in the males body weights, sperm count, individual and massive sperm
motility, testes weights, and epididymis weights as compared with control and (T4,
T5, T6 and T7) groups at (P≤0.05).When Quercetin dihydrate was offered as an
ameliorating agent, it showed a significant ameliorating effect by increasing the body
weights, sperm count, individual and massive sperm motility, testes weights, and
epididymis weights . When Quercetin dihydrate was offered alone in the ration of the
sixth treated group (T6), it caused clear significant ameliorating effect on all sperm
parameters comparing with all treated groups and the sperm count was even
significantly higher than that of control group while the other aspects were similar to
those of control group at (P≤0.05). Beside, O-anisidine caused significant decrease in
the number of pregnant females, number of delivered litters, weight of litters and sex
ratio, and it prevented the pregnancy from being occurred in the group where both
male and females are treated with it (T1). When Quercetin was mixed with Oanisidine
in the ration of (T7), it significantly ameliorated the pregnancy chances,number of litters and the sex ratio as compared with the other groups but it didn’t
reach to significant level with control group at (P≤0.05).