Author
Abstract
The study was conducted to determine the effect of the 5-Fluorouracil (5-FU) drug is a
medication used to treat cancer or the knowledge of 5-FU drug(anticancer) effect might help to
attribute these side on physiological and biochemical parameters in human by injection into a vein it is
used for colon cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer and cervical
cancer. 80 blood samples were obtained adult human divided into two groups for each group (n = 40),
the first group (control) and the second group treatment with drug 5-fluorouracil.
There are a significant decrease (P <0.05) in the blood parameters included parameters Red
blood cells count, the total number of white blood cells, platelets , hemoglobin and packed cell volume
in men treatment with 5-fluorouracildrugcompared with control group. Causing the 5-FU drug
significant decrease(P<0.05) in Triglycerides, cholesterol levels and total protein in the treatment group
compared with control group. Also, the result showed a significant increase in Creatinine level of
second group in compared with control group, while the results showed non- significant in urea level in
human treatment when compared with control group.
The results showed a significant decrease (P <0.05) in the level of liver enzymes, (ALT AST and
ALP) in the treatment group with 5-FU when compared with the control group.
Keywords
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