Author
Abstract
The oral use of pregabalin was evaluated in this study to reveal its effects on some
hematological and biochemical parameters of laboratory mice. The animals of this
study were divided into three groups (twelve mice each). The control group was fed
on a standard ration. The first treated group (Pregabalin 1) were dosed orally with one
ml of distilled water containing Pregabalin (20 mg/ml/mice/ day). The second treated
group (Pregabalin 2) were dosed orally with one ml of distilled water containing
pregabalin (40mg/ml/mice/ day). The experiment continued for two successive
months. The results showed that the use of pregabalin caused a significant declination
in R.B.C., HGB, HCT, W.B.C., M.C.V., MCH, and MCHC of both treated groups
compared them with control group and the declination was more significant in
(pregabalin 2) group compared with (pregabalin 1) group. The RDW-CV, RDW-SD,
and PLT increased significantly in both treated groups as compared with those of the
control group. However, PCT, PDW and MPV were not affected by the use of
pregabalin except the MPV of (Pregabalin 2) group was significantly less than that of
(Pregabalin 1) but without a significant difference compared with that of control. The
Fe++, and GLU decreased significantly in both treated groups compared with the
control and they declined more significantly in (Pregabalin 2) compared with
(Pregabalin 1). Both the TP and Ca++ did not affected by the use of pregabalin
compared with the control group (P≤0.05)
Keywords
)
