Document Type : Research Paper
Authors
1 branch of Internal medicine/ veterinary medicine college/ University of Al-Qadisiyah/ iraq
2 Branch of Internal medicine / veterinary medicine college/ Al-Qadysiyah university/ Iraq
3 college of dentistry/ college of -Qadysiah
4 branch of Basic science/ college of dentistry / university of Al-Qadysiah / Iraq
Abstract
lupus is an autoimmune disease that occurs in animals and humans, characterized by producing autoimmune antibodies against its cells proteins. The present study investigates the tissues changes of the liver in BALB/c mice with lupus and investigation the effects of bone marrow-derived mesenchymal stem cells (BM-MCSs) for treatment of the tissues pathological changes. The study included forty BALB/c mice, the animals divided into equally four groups. G1 included mice with lupus. G2 included mice with lupus, then treated by BM-MCSs. G3 are administered BM-MCSs alone. G4 administrated PBS. After ending the treatment periods, all the animals were sacrificed. The liver was placed in buffer formalin 10% and sent to the histopathology laboratory to determine the histopathological changes in all study groups. The histopathological changes of G1 are liver severe necrosis with atrophy, hydropic lever cells, very wide sinusoids, severe hemorrhage, and engorged central vein. G2 showed normal lever cells with slight necrosis. G3 and G4 showed normal architecture of the liver tissue. Lupus causes histopathological changes in the mice's liver; MSC can ameliorate and treat the liver's histopathological changes in BLAB/c mice with lupus.
Keywords
Article Title [العربیة]
دراسة نسجية مرضية لكبد الفئران BALB/C المصابة بمرض الذئبة الاحمراري والمعالجة بالخلايا الجدعية الميزنكيمية من نخاع العظم
Authors [العربیة]
- غسان اسماغيل 1
- حسن علاوي 2
- نور مجيد 3
- وجدان غبد الحسين 4
1 فرع الطب الباطني/ كلية الطب البيطري/ جامعة القادسية/ القادسية/ العراق
2 فرغ الطب الباطني / كلية الطب البيطري/ جامغة القادسية/ محافظة القادسية/ العراق
3 طب الاسنان/ جامعة القادسية
4 فرغ العلوم الاساسية/ كلية طب الاسنان؟ جامعة القادسية/ العراق
Keywords [العربیة]
- الفخص النسيجي
- الكبد
- فئران BALB/C
- الذئبة الاحمراري
- الخلايا الميزنكيمية الجذغية
)
