Basrah Journal of Veterinary Research

Histopathological Study of the Liver in Balb/C Mice with Lupus Treated by Bone Marrow-Derived Mesenchymal Stem Cells (Bm-Mscs)

Document Type : Research Paper

Authors

Ghassan Khudhair Esmael 1
Hassan Khalaf Ulaiwi 2
Noor Mahmood Majed 3
Wijdan Mirza abd Al Hussein 4

1 branch of Internal medicine/ veterinary medicine college/ University of Al-Qadisiyah/ iraq

2 Branch of Internal medicine / veterinary medicine college/ Al-Qadysiyah university/ Iraq

3 college of dentistry/ college of -Qadysiah

4 branch of Basic science/ college of dentistry / university of Al-Qadysiah / Iraq

https://doi.org/10.23975/bjvr.2024.150642.1100
Abstract
lupus is an autoimmune disease that occurs in animals and humans, characterized by producing autoimmune antibodies against its cells proteins. The present study investigates the tissues changes of the liver in BALB/c mice with lupus and investigation the effects of bone marrow-derived mesenchymal stem cells (BM-MCSs) for treatment of the tissues pathological changes. The study included forty BALB/c mice, the animals divided into equally four groups. G1 included mice with lupus. G2 included mice with lupus, then treated by BM-MCSs. G3 are administered BM-MCSs alone. G4 administrated PBS. After ending the treatment periods, all the animals were sacrificed. The liver was placed in buffer formalin 10% and sent to the histopathology laboratory to determine the histopathological changes in all study groups. The histopathological changes of G1 are liver severe necrosis with atrophy, hydropic lever cells, very wide sinusoids, severe hemorrhage, and engorged central vein. G2 showed normal lever cells with slight necrosis. G3 and G4 showed normal architecture of the liver tissue. Lupus causes histopathological changes in the mice's liver; MSC can ameliorate and treat the liver's histopathological changes in BLAB/c mice with lupus.

Keywords

Histopathological Examination
liver
BALB/c mice
lupus
MSCs

Article Title العربیة

دراسة نسجية مرضية لكبد الفئران BALB/C المصابة بمرض الذئبة الاحمراري والمعالجة بالخلايا الجدعية الميزنكيمية من نخاع العظم

Authors العربیة

غسان اسماغيل 1
حسن علاوي 2
نور مجيد 3
وجدان غبد الحسين 4
1 فرع الطب الباطني/ كلية الطب البيطري/ جامعة القادسية/ القادسية/ العراق
2 فرغ الطب الباطني / كلية الطب البيطري/ جامغة القادسية/ محافظة القادسية/ العراق
3 طب الاسنان/ جامعة القادسية
4 فرغ العلوم الاساسية/ كلية طب الاسنان؟ جامعة القادسية/ العراق

Keywords العربیة

الفخص النسيجي
الكبد
فئران BALB/C
الذئبة الاحمراري
الخلايا الميزنكيمية الجذغية
Basrah Journal of Veterinary Research
Volume 23, Issue 3
Summer 2024
Page 24-33

  • Receive Date 06 June 2024
  • Revise Date 28 June 2024
  • Accept Date 02 July 2024
  • Publish Date 30 September 2024

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