Background: Moringa oleifera gained its importance as a natural antioxidant due to its high content of phenolic compounds, such as flavonoids and phenolic acids. Aim: The present experience was designed to assess the ability of extract of moringa leaves to prevent cardiac infraction in male rats with hypothyroidism. Methodology: 30 male rats were distributed in 2 groups, healthy group 10 rats and hypothyroid 20 rats. Hypothyroid was induced by administering 1mg/ml propylthiouracil (PTU) in drinking water for two months. After confirmed thyroid deficiency induced by measuring thyroid function test, showing low thyroid hormones levels and high TSH, animals were distributed equally into three groups 10 rats each, as follows; first group (intact animals ) as negative control, rats were administered (1ml) of normal solution, second group (hypothyroidism untreated), as positive control, rats were administered (1ml) of PTU, third group (HYPO-MOE treated), rats treatment with MOE at a dose 300 mg/kg, the treatment continued for one month. Results: The oral administration of PTU resulted pronounced reduction in the levels of thyroid hormones concomitantly with significantly elevation in TSH and lipid profile concurrently with diminished in the level of HDL, also results revealed elevation in heart enzymes activity accompanied by elevation of troponin I associated with histological changes in myocardial architecture whereas the treatment with MOE resulted in improvement the thyroid function, lipid profile, cardiac biomarkers and restoration of cardiac architecture.