L-Arginine has hypoglycemic and antioxidant effect in Alloxan diabetic animals
and reduce effect of diabetes complication on spermatogenesis. antioxidant have
essential effect on spermatogenesis, L-Arginine has antioxidant and hypoglycemic
effect. Enhanced oxidative stress and changes in antioxidant capacity are considered
to play an important role in the pathogenesis of chronic diabetes mellitus.
Sixteen mature male rats aged 10 weeks ,were randomly divided into four equal
groups as follows 1st diabetic group (DG) that received 150 mg/kg (IP) Alloxan
single dose ;2nd group diabetic group treated with (L-Arginine-Hcl)(DAG) received
150mg/kg (IP) Alloxan as single dose plus L-Arginine-Hcl 200mg/kg(IP)-per day, 3ed
group treated with(L-Arginine-Hcl)(AG) received 200mg/kg-(IP) perday ,and 4th were
control group(CG) non treated .In 60 day the blood samples collected from heart to
make serological parameters (glucose level) and testes removed to observe their
Histopathological.
Serum Glucose concentration showed a significant increase (p<0.05) in diabetic
group (DG) compared with other groups while diabetic treatment group that has
received L-Arginine 200 mg/kg(IP) (DAG) showed a significant (p<0.05) decrease
compared with (DG).