This study was conducted to investigate the effect of chitosan sheets on
A inflammation. Accordingly chitosan sheet was isolated and prepared from the
exoskeleton of the native shrimps in Basrah Province. The inflammation was induced and
evaluated by polyvinyl sponge to determine the events which occur during the
inflammatory process during different intervals in the presence or absence of chitosan
‘ sheets .For this purpose 24 male rabbits were used and two linear skin incisions (2 cm)
were made on the dorsal aspect in both sides of each rabbit. The inflammatory process at
l,3,7&l5 day post wounding was evaluated macroscopically in terms of hyperemia,
suppuration, dryness, and adhesion of margins and microscopically in terms of infiltration
of inflammatory cells specially neutrophils and macrophages, fibrovascular granulation
tissue. _
. The ‘results of macroscopic evaluation revealed that '-It first post wounding day the
test wound was significantly (p<0.05) more hyperemic than control wounds followed by
a significant decrease in the severity of hyperemia in test wounds at ls‘, 3rd, 7"‘, and 15"‘
post wounding days (p<0.05). The test wounds was more dry with less suppuration to
_ words the end of the experiment than control wounds (p<0.05). The adhesive contact
between the margin of the wounds was significantly higher in test wounds than in control
wounds through out the period of experiment (p<0.05).