This study aimed to evaluate the effect of the drenching ethanolic extract of Chamomile and licorice at a dose of (100 mg/kg and 250 mg/kg ) respectively in treating gastric ulcer induced by aspirin in rabbits. The study included the effect of drenching the ethanolic extract of both plants on the gastric ulcer index ,gastric juice pH, and volume of gastric fluid as well as curative ratio. Results revealed that treatment with cemitidine and Chamomile or licorice or their combination was associated with significant(p<0.05) increase in pH values compared to the respective value of the untreated (positive) group. Chamomile or licorice was superior to that of cimetidinee and to combiation of the extracts. Groups treated with cemitidine and drenching of Chamomile or Licorice were associated with significant (p<0.05) reduction in the volume of gastric juice compared to positive and control groups, a group treated with a combination of extracts caused significant (p<0.05) reduction in gastric juice volume compared to positive group. A curative ratio of gastric ulcer was better in groups given chamomile or licorice over those given cemitidine or combination of chamomile and licorice. Furthermore, chamomile was superior over licorice in its curative ratios of gastric ulcer.
In view of above results we can conclude that a drenching ethanolic extract of Chamomile and licorice in the doses used in this study caused increased gastric ulcer healing compared with treatment by 200mg/kg of cimetidinee in treatment gastric induced by Aspirin in rabbits.