This study was done to evaluate the hypoglycemic potentials of ginger
(zingiber officinale ) in controlling hyperglycemia ,hypoinsulinemia and their
effect on total cholesterol in cadmium-induced pancreotoxicity in male rabbits
Twenty four of adult male rabbits were divided randomly into four equal groups.
Group 1 was given distilled water orally and considered as control group, group 2
received 10mg/kg B.w of cadmium chloride, group 3 received 100mg/ kg B.w of
ginger extract plus 10mg/kg B.w of cadmium chloride and group 4 received
200mg/ kg B.w of ginger extract plus 10mg/kg B.w of cadmium chloride. All
treatments were given a daily dose for 35 days.
The blood sample was taken from these animal groups after 35 days of treatment
for biochemical analysis to estimate : insulin hormone, blood glucose ,total
cholesterol, Aspartate amino transferase (AST) , Alanine aminotranferase(ALT)
and Alkaline phosphatase (ALP).
The results showed that cadmium chloride administration resulted in a decrease in
the level of insulin concentration associated with an increase in glucose and total
cholesterol concentration in rabbits .The enzyme activities of serum ALT, AST and
ALP were also significantly increased . While , the groups of animal that received
ginger showed significant decrease in serum glucose , cholesterol , AST, ALT and
ALP. The level of insulin was also increased in these groups of animal.