The aim of this study investigate the effects of long term administration of
Dexamethasone (DEX.) 17 β-estradiol (EST.) on body weight, concentration of some
hormones ( Leptin, thyroid and reproductive hormone) in addition to determination of
lipid profile of female rabbits blood serum.
Thirty local rabbits were subdivided randomly and equally into three groups. The
first group was used as a control which injected with normal saline . The second group
was injected daily (0.5mg /kg B.W) DEX . Intramuscularly. The third group was injected
subcutaneously daily with 0.3 mg /kg B.W s/c 17 β-estradiol. All groups in this study
were treated for 60 days , and blood collected every 15 days. Serum was tested for leptin,
LH, FSH, T3, T4 hormones total Cholesterol(TC), HDL(height density lipo-protein),
LDL (low density lipo- protein),TG (triglycerides), Body weight was taken every 15 days
from the first day .
The result showed significant (P≤0.05) decreased in body weight after
administration of both dexamethasone (DEX.) and Estrogen (EST.), significant increased
in leptin concentration with dexamethasone (DEX.) Treatment while significant
decreased with Estrogen (EST.) treatment, in the other hand LH and FSH concentration
showed significant decreased in both treatment dexamethasone (DEX.) and Estrogen
(EST.) thyroid hormone show significant decreased with dexamethasone (DEX.)
Treatment and significant increased T3 & T4 hormone with Estrogen (EST.) treatment as
compare with control while the increase in the T4 it was occurred only in the periods (45and 60)days within treatment groups , lipid profile (TC,TG,LDL, HDL,VLDL) show
significant increased with DEX. treatment while Significant decreased with EST.
treatment