Basrah Journal of Veterinary Research

HISTOPATHOLOGICAL STUDY OF SEPSIS EXPERIMENTALLY INDUCED BY CECAL LIGATION AND PUNCTURE IN RATS

Author

A. M. Al-Saidya H. Kh. Ismail
https://doi.org/10.33762/bvetr.2013.76193
Abstract
The aim of this study was to investigate the histopathological lesions in the
liver,kidney and lung sections in rats with sepsis that experimentally induced by cecal
ligation and puncture CLP procedure to induce intra-abdominal infection. It was found
that CLP models leads to higher mortality rate comparisons to sham-operated and un–
operated animals. Also there were severe lesions in the liver , kidney and lung of rats
with sepsis , characterized by severe massive necrosis in hepatic cells , while the
histopathological changes in kidney of CLP rats revealed severe glomerulonehritis with
infiltration of inflammatory cells , in lung , severe interstitial and bronchial pneumonia ,
with presence of severe thickening of blood vessel wall with thrombi . In conclusion, the
results of this study have demonstrated that CLP induces high mortality rate , an acute
systemic septic state with multiple organ dysfunction especially the Liver , kidney and
Lung based on histopathological observations . These features were not observed in sham
- operated or un-operated rats .

Keywords

sepsis
CLP
glomerulonehritis

Article Title العربیة

د ا رسة مرضية نسجية للانتان المحدث تجريبياً بواسطة ربط الاعور وثقبه في الجرذان

Author العربیة

أحمد محمد علي السيدية
Basrah Journal of Veterinary Research
Volume 12, Issue 1
Spring 2013
Page 104-115

  • Receive Date 01 June 2013
  • Revise Date 20 June 2013
  • Accept Date 25 June 2013
  • Publish Date 28 June 2013

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