Author
Abstract
Forty adult male Bulb/c mice weighing between 25-30 GM reared in wire cages were
randomly divided into four groups (10 mice each group). Group (G1) received the regular mice diet
and (1 ml/kg Saline p.o.) for 8 days maintained as a control group. Group (G2) treated daily intra
peritoneal (i.p) injection of gentamicin (40m g/kg bwt /day) for 8 days. In group (G3) received
Gum Arabic (GA) (10 gm /kg bwt /day) for 8 days orally by using stomach tube. Group (G4) is
received gentamicin (40 mg/ kg bwt /day) (i.p) plus (10gm /kg bwt / day) orally of Gum Arabic for 8
days. Blood samples were collected after overnight fasting 12-24 hours for determination some
biochemical marker including AST, ALT and ALP activities, creatinin, uric acid , urea and total
bilirubin in serum . Assay the total protein, Deoxyribonucleic acid DNA, ribonucleic acid RNA in
liver tissue of mice.
The results revealed that treatment with gentamicin (G2) increased in AST, ALT and ALP activities
in serum, creatinine, uric acid, urea and total bilirubin value in serum also there are elevation
the level of DNA, RNA and total protein in liver tissue when a compared with the control group
(G1).Treatment of GA along with gentamicin (G4) and administration of GA alone (G3) decreased in
the level of serum creatinine, serum uric acid, serum urea and serum total bilirubin , the level of
DNA, RNA and total protein in liver tissue also decrease, as compared to the gentamicin treated
group (G2) but not reach in both groups(G3,G4) to normal level as in control group.
In conclusion Gum Arabic exhibit hepatoprotective activities probably through free radical
scavenging properties. Altered level of hepatic markers such as AST, ALT, and ALP with gentamicin
exposure was reversed towards normalization with Gum Arabic. Similarly, biochemical parameters were
also restored by Gum Arabic. Bioactive of Gum Arabic ameliorated the oxidative damage and had
increased the regenerative and reparative capacity of liver.
Keywords
Article Title [العربیة]
دراسة تأثير الكيموحيوي للصمغ العربي في أكباد ومصل الدم لذكور الفئران المصابة بالتسمم الكبدي المحدث بالمضاد الحيوي جنتاميسين
Author [العربیة]
- غسان فتحي محمد العبيدي
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