Basrah Journal of Veterinary Research

STUDY THE EFFECT OF EXOGENOUS ESTROGEN ADMINISTRATION ON PROSTATE GLAND OF LABORATORY WHITE MICE (MUS MUSCULAUS)

Author

Mukhallad A. Ramadhan
https://doi.org/10.33762/bvetr.2013.76208
Abstract
A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ERα and ERβ, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. 24 male mice divided into four groups as following : negative control, low dose group, intermediate dose group and high dose group, the groups of treatment were injected with estrogen at different doses while the negative control group were injected with normal saline (by method of intramuscular injection for all groups) and after 6 weeks all animals had been killed and the prostate was picked up and sectioned to reveal the histopathological changes. the study found that the injection of exogenous estrogen result in marked hyperplasia of the prostatic tissue and the hyperplasia increased significantly with elevation of the estrogen dose. In conclusion injection of exogenous estrogen lead to prostate hyperplasia through its action on the estrogen receptors which present in both stromal and epithelial component of the prostate

Keywords

Estrogen
ESR
prostate

Article Title العربیة

دراسة تاثير الحقن الخارجي للاستروجين على غدة البروستات في الحيوانات المختبرية البيضاء

Author العربیة

مخلد عبد الكريم رمضان
Basrah Journal of Veterinary Research
Volume 12, Issue 1
Spring 2013
Page 275-285

  • Receive Date 01 June 2013
  • Revise Date 20 June 2013
  • Accept Date 25 June 2013
  • Publish Date 28 June 2013

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