Authors
Abstract
This study was conducted to evaluate the effects of cyclosporine on some
hematological indices in male rabbits after bone marrow transplantation operation. Thirty
male rabbits were used in the present study which divided into three groups equally (ten
rabbit each group).Rabbit of first group were give0.5 ml of normal slain from Day zero
till Day 10 of experiment then applied to intra bone marrow-Bone marrow transplantation
(IBM-BMT) at Day 11 then after, these rabbit give normal slain from Day 12 till Day 20
and considered as shame group. Rabbits of second and third groups were applied to same
protocol that used in first group except that the rabbit were give 12.5 (T1) and (T2) 25
mg/kg/BW of cyclosporine respectively instead of normal slain.
blood was collected At Day10 and Day 21 from all rabbit of the experiment via
heart puncture and Red blood cell (RBCs)count , white blood cell (WBCs) count,
Deferential leukocyte count, Packed cell volume(PCV) and hemoglobin
concentration(Hb) were measured.
Results of the present study showed significant decrease (p<0.05) WBCs count,
Neutrophils, Lymphocytes, in groups treated with 12.5 and 25 mg/kg/BW in compare to
shame group at Day 10 and Day 21whileRBCs count, PCV and Hb values were
significantly decrease (p<0.05) T1 and T2 groups compare with that in shame group at
Day 10 only then return to normal at Day 21.
Results of the present study suggested that the cyclosporine at both doses act as immune
suppresser in bone marrow transplanted- rabbits.
Keywords
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