Authors
Abstract
Bis[4-(4'-hydroxy-3'-methoxy benzylidene amino phenyl)] telluride (R2Te) was
prepared from the reaction of two moles of 4-(4'-hydroxy-5'-methoxybenzylidene amino
phenyl) mercuric chloride and one mole of TeBr
4
in dry dioxane to give diorganyl
tellurium dibromide (R
2
TeBr2
) which reduced by boiling ethanolic hydrazine hydrate to
give the corresponding new telluride (R
2
Te).
R2
Te inhibits nitrite induced methemoglobin formation in hemolysate. The time
required to convert 50% of the available hemoglobin to methemoglobin was increased
from 2.5 to 4, 5.5 and 10.5 minutes by the addition of (1.25, 5 and 20µM) of test
compound (R
2
Te) respectively, and from 7 to 15, 29 and 54 minutes to convert all of the
available hemoglobin to methemoglobin. It seems that R
2
Te failed to inhibit nitrite
induced hemoglobin oxidation if added after the autocatalytic stage (5-10 minutes after
nitrite addition). R
2
Te, a novel organotellurium compound, can inhibit nitrite induced
methemoglobin formation in hemolysate in a dose dependent manner if added before the
autocatalytic stage.
Keywords
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