Basrah Journal of Veterinary Research

HISTOPATHOLOGIC CHANGES IN RAT ORGANS UPON CHRONIC EXPOSURE TO FORMALDEHYDE VAPOR

Authors

Snur Muhammad Amin Hassan
Azad Kareem Saeed
Nabil Abdul-Massih Salmo
Ahmed Hamdi Mehdi
Nali Abdulqadr Maaruf
https://doi.org/10.33762/bvetr.2014.98805
Abstract
The present study was carried out to detect histopathologic lesions in different
rat organs after chronic exposure to formaldehyde vapor. Forty adult albino Wistar
rats were used in this experiment. Animals were divided into two groups; Control
group (n=10; 5 males and 5 females) which were not exposed to formaldehyde at all,
while the remainders regarded as the experimental group (exposed to formaldehyde
for 21 days, n=30; 15 males and 15 females). The histopathologic examination in our
study revealed several changes in exposed group such as; chronic tracheitis, squamous
metaplasia of lining epithelium and tracheal glands with occurrence dysplasia in the
lining epithelium, interstitial pneumonia, hydropic degeneration in the hepatocytes,
epidermal hyperplasia, interstitial glomerulonephritis with atrophy of glomeruli. We
concluded that the overexposure of formaldehyde produced lesions in different organs
but their toxic effects were seen predominantly in respiratory system.

Keywords

Tracheitis
Formaldehyde
Wistar rats
Basrah Journal of Veterinary Research
Volume 13, Issue 2
Autumn 2014
Page 127-140

  • Receive Date 01 December 2014
  • Revise Date 20 December 2014
  • Accept Date 25 December 2014
  • Publish Date 28 December 2014

Home

Self Archiving Policy

Copyright Policies

Digital archiving

Open Access Statement

Authorship

Guide for Authors

Submit Manuscript

Contact Us

Journal Metric

Publication Fee