Authors
- Snur Muhammad Amin Hassan
- Azad Kareem Saeed
- Nabil Abdul-Massih Salmo
- Ahmed Hamdi Mehdi
- Nali Abdulqadr Maaruf
Abstract
The present study was carried out to detect histopathologic lesions in different
rat organs after chronic exposure to formaldehyde vapor. Forty adult albino Wistar
rats were used in this experiment. Animals were divided into two groups; Control
group (n=10; 5 males and 5 females) which were not exposed to formaldehyde at all,
while the remainders regarded as the experimental group (exposed to formaldehyde
for 21 days, n=30; 15 males and 15 females). The histopathologic examination in our
study revealed several changes in exposed group such as; chronic tracheitis, squamous
metaplasia of lining epithelium and tracheal glands with occurrence dysplasia in the
lining epithelium, interstitial pneumonia, hydropic degeneration in the hepatocytes,
epidermal hyperplasia, interstitial glomerulonephritis with atrophy of glomeruli. We
concluded that the overexposure of formaldehyde produced lesions in different organs
but their toxic effects were seen predominantly in respiratory system.
Keywords
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