Authors
Abstract
Sodium nitrite is widely used as a color fixative and preservative in meat and fish.
Impairment of hepatic function and disturbances in lipid metabolism are well recognized
adverse effects of sodium nitrite. The aim of this study is to investigate the role of bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride, a novel compound, in
preventing the hepatic damage and disturbances of lipid metabolism induced by sodium
nitrite toxicity in male albino rats. The estimated LD50 of [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride in adult male albino rats is 218.7 mg/kg body
weight. Rats given sodium nitrite (0.2%) in the drinking water showed a significant
increase in serum ALT, AST, ALP, Total cholesterol, TG. LDL and VLDL while HDL
significantly reduced. These changes are reversed by administration of bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride in a dose of 11mg/kg body weight
corresponding to 1/20 LD50. It is concluded that bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride is effective in preventing hepatic damage and
dislipidemia in sodium nitrite intoxicated male rats.
Keywords
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