Authors
Abstract
In recent years, pyrazole and pyrimidine derivatives attracted organic chemists due
to their widespread potential biological and chemotherapeutic activities. In this
study, pyrimidine derivative namely 6-Chloro-2,4-diamino pyrimidine was screened
for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus
cerius, Streptococcus spp, Klebsella- spp and salmonella spp and fungicidal activity
against Aspergillus multi, Aspergillus niger and Candida albicans. A compound
exhibited low antibacterial and antifungal activity with the reference standard
Streptomycin, Vancomycin and Nystatin respectively.
The toxicity of the compound was also assayed via the determination of their LD50
value by using Dixon
,
s up and down method (1980). Studied compound was found to
have an LD50 of 518.6 mg / kg of body weight.
Keywords
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