Basrah Journal of Veterinary Research

AMELIORATIVE ROLE OF SILYMARIN EXTRACTED FROM SILYBUM MARIANUM SEEDS ON NICKEL CHLORIDE INDUCE CHANGES IN TESTICULAR FUNCTIONS IN ADULT MALE RABBITS.

Authors

Abdul Razak N. Khudair
Eman A . AL-Masoudi
Wasfi Dh Abid Ali
https://doi.org/10.33762/bvetr.2015.99994
Abstract
This study aimed to investigate the Ameliorative effect of ethanolic extracted
of silymarin from Silybum marianum seeds and to compare it’s with the
commercial silymarin extract(legalon) against oral dosing of Nickel chloride effects
on sperms concentration, motility ,viability, sperm abnormality and male fertility
and gonadal hormones .Twenty adult male rabbits aged 5 to 6 month and weighted
1.250-1.500 kg divided into four equal groups,1
st
group served as control group
received 1 ml of normal saline (NaCl 0.9%),2
nd
group received (1mg/100g B.W
)NiCl2 orally, 3
rd
group received same dose of NiCl2 plus (0.1mg/100g B.W)
silymarin extract, the fourth group received same dose of NiCl2 plus (0.1mg/100g
B.W) legalon for 35 days, Results showed negative effects of NiCl2 which caused
significant(p≤0.05) decrease in sperm concentration ,viability, motility and fertility
while sperm abnormality was significantly increase, also NiCl2 caused significant
(p≤0.05) decrease in serum progesterone, estradiol and testosterone. while silymarin
extract and legalon adverse the negative effects of NiCl2 and causing ameliorative
effects on all the studied parameters .

Keywords

Ameliorative
Silymarin
sperm abnormality
Basrah Journal of Veterinary Research
Volume 14, Issue 1
Spring 2015
Page 135-144

  • Receive Date 01 December 2015
  • Revise Date 20 December 2015
  • Accept Date 25 December 2015
  • Publish Date 01 June 2015

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