Authors
Abstract
This study was designed to evaluate the ameliorative effect of selenium on
reproductive efficiency of adult male rats with thyroid disturbance.
Hypothyroidism state was induced by administration of antithyroid drug propylthiouracil
(PTU) (50mg/kg.B.W.) and hyperthyroid state was induced by administration of LThyroxine(L-T4) (50μg/kg.B.W.). Selenium (Se) treated rat group was given sodium
selenite (10 μg/kg.B.W.).
Sixty adult male rats of (180-200 gm) body weight were used in this study and divided
into six main groups. Control group, PTU treated group, L-T4 treated group, Se treated
group, Se+PTU treated group and Se+L-T4 treated group. All these groups were
drenched orally by gavage tube for two months.
The obtained results revealed that hypothyroidism is accompanied by significant
(P<0.05) decrease in serum T3, T4 concentrations compared with control and another
treated groups and significant increase (P<0.05) in hyperthyroidism group a compared
with control. On the other hand, TSH concentration showed a significant (P<0.05)
increase in hypothyroidism group and significant decrease (P<0.05) in hyperthyroidism
group as compared with control and another treated group.
A significant decrease in serum concentrations of FSH, LH and testosterone have been
shown in serum of hyper- and hypothyroidism groups.
Semen analysis showed a significant decrease (P≤0.05) of epididymal sperm
concentration, sperm motility, and viability and a significant increase (P≤0.05) of sperm22
abnormalities were recorded in PTU and L-T4 groups compared with control and another
treated group. While a significant increase (P≤ 0.05) of epididymal sperm concentration,
sperm motility and viability and a significant decrease (P≤ 0.05) of sperm abnormalities
were recorded in Se alone, Se+PTU group and Se+L-T4 group. Also, histological
examination on the testis showed that rats treated with Se, Se+PTU and Se+L-T4 had
normal architecture of seminiferous tubules with different stage of spermatogenesis.
Whereas, rats treated with L-T4 alone or with PTU exhibited vacuolation of
spermatogonia and suppression of spermatogenesis.
Keywords
Article Title [العربیة]
AMELIORATIVE EFFECT OF SELENIUM ON REPRODUCTIVE EFFICIENCY IN ADULT MALE RATS WITH THYROID DISTURBANCE
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