OVERDOSEOF TUSSIRUM INDUCED HISTOPATHOLOGICAL CHANGES OF THE LIVER AND KIDNEY IN MALE DOMASTIC RABBITS

M. Abd Al Rahmman, Zenab; J. Mohammed, Yasmeen; J. Rasmy, Abdal; F. Majeed, Majdy

doi:10.33762/bvetr.2018.143560

OVERDOSEOF TUSSIRUM INDUCED HISTOPATHOLOGICAL CHANGES OF THE LIVER AND KIDNEY IN MALE DOMASTIC RABBITS

Authors

Zenab M. Abd Al Rahmman

Yasmeen J. Mohammed

Abdal J. Rasmy

Majdy F. Majeed

https://doi.org/10.33762/bvetr.2018.143560

Abstract

In this study, the histopathological changes due to overdose usage of Tussirum
drug(0.75 and 3 ml/Kg)in liver and kidney were assessed in rabbite with light
microscopes. Six male rabbites(1 ± 0.5 Kg ) were included and divided into three
groups.Normal saline (3ml/Kg) wasgiven orally as placebo in the control groupI (N= 2).
Group II and III(N= 4 for each) was received Tussirum orallyat a single dose of (0.75 and
3ml/kg/day) for 30 days respectively. the results were recorded that both doses of
Tossirum were induced that blood vessel congestion, aggregation of Kuppfer
cells,inflamintion infiltrations and Sinusoidal dilatation in the liver parenchyma in
addition to the cytoplasmic vacuolation, degeneration, pyknotic nuclei in the hepatocytes
and. On the other hand, renal damage was observed in the kidneys of treated rabbits,
necrosis of glomular, degeneration of nucli and degeneration in the lining epithelial cells
of renal, also noted that glomular shrinkage, dilated of reanal tubules and hyperplasia of
tubles walls,as well as to necrosis of renal tubules endothelium, closing of renal tubules
lumen, isulation of renal tubules endothelium and density in some nucli chromatic
Finally, the investigators concluded that Tossirum toxicity induced hepatocellular and
renal damage

Keywords

Tossirum

liver

Male Rabbit

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