Author
Abstract
The oral use of pregabalin was evaluated in this study to reveal its effects on
some hematological and biochemical parameters of laboratory mice. The animals of
this study were divided into three groups (twelve mice each). The control group was
fed on a standard ration. The first treated group (Pregabalin 1) were dosed orally with
one ml of distilled water containing Pregabalin (20 mg/ml/mice/ day). The second
treated group (Pregabalin 2) were dosed orally with one ml of distilled water
containing pregabalin (40mg/ml/mice/ day). The experiment continued for two
successive months. The results showed that the use of pregabalin caused a significant
declination in R.B.C., HGB, HCT, W.B.C., M.C.V., MCH, and MCHC of both
treated groups compared them with control group and the declination was more
significant in (pregabalin 2) group compared with (pregabalin 1) group. The RDWCV, RDW-SD, and PLT increased significantly in both treated groups as compared
with those of the control group. However, PCT, PDW and MPV were not affected by
the use of pregabalin except the MPV of (Pregabalin 2) group was significantly less
than that of (Pregabalin 1) but without a significant difference compared with that of
control. The Fe++, and GLU decreased significantly in both treated groups compared
with the control and they declined more significantly in (Pregabalin 2) compared with
(Pregabalin 1). Both the TP and Ca++ did not affected by the use of pregabalin
compared with the control group (P≤0.05)
Keywords
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