Abstract
The present study aimed to determine the potential toxic effects of Nizoral through oral
administration on some of blood and biochemical parameters of laboratory rabbits .
Eighteen of local normal rabbits were used in the present study . The animal divided
randomly to three group ( six animal in each ) .Group one ( control ) the animal treated
normal saline .Group two the animals chronically feed by stomach tube Nizoral 20
mg/kg/BW daily for 30 days. Group three the animals chronically feed by stomach tube
Nizoral 40 mg/kg/BW daily for 30 days. The investigation included body weight gains
(BW) , some blood parameters like red blood cells count (RBC) hemoglobin
concentration(Hb), packed cell volume (PCV) and total white blood cell count(WBC) .
Biochemical parameters included total serum alan in aminotransferase (ALT), aspartate
aminotransferase(AST),and hormones testosterone concentration ,and semen
characteristics .The results showed reduced in BW. R.B.C count ,Hb concentrations PCV
value were reduced gradually but not reach a significantly . Total W.B.C count
lymphocyte and monocyte appeared a significant decrease(p≤0.05) ,but neutrophils
showed a significant increase (p≤0.05).The biochemical study refers to a significant
increase (p≤0.05) in ALT,AST and a significant decrease(p≤0.05) in hormones
testosterone concentration.The testes and epididymis appeared absences of sperms .
Keywords
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